Books and Monographs

Methods for Computational Gene Prediction
by William H. Majoros
Genre: Science / Technical
Publication date: September 2007
Publisher: Cambridge University Press

Secrets of Digital Bird Photography
by William H. Majoros
Genre: Instructional
Publication date: August 2010
926 pages, 662 full-color illustrations

Read it online!  Click HERE

A Season with the Osprey
by William H. Majoros
Genre: Nature / Ornithology
Publication date: November 2008
Softcover, 100 pages

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Or click here to read the lo-res web version.

The Hélethrônium
by William H. Majoros
Genre: Sci-fi / Fantasy
Publication date: 2004
Hardcover, 663 pages

Now available for reading online,

 Current Projects (in Progress)

Lucifer's Ark
A Historical Thriller

Download the first 13 chapters HERE.

Dr. Morrow’s research in Egypt is suddenly interrupted when his impetuous nephew Lance Nigel claims to have found an artifact unlike any found before.  When his nephew later turns up dead under questionable circumstances, Morrow takes it upon himself to discover the truth behind his cousin’s death.  Across Israel and ancient Mesopotamia Morrows team follow Nigel’s trail—a search for an artifact so politically explosive that it could lead to the next world war.  Meanwhile, Nigel's murderers regoup to oppose Morrow, dogging him at every turn.  To the very brink of world war the artifact leads—before international powers intercede to cut a deal and suppress the find.  In the end, it’s up to Morrow to decide whether to go along with their deal: to hide the truth forever, or to reveal it and risk worldwide catastrophe.

The Bird: Evolution's Masterpiece
by William H. Majoros
Genre: Science / Natural History
Projected publication date: TBD

Bioinformatics Programming in C++
by William H. Majoros
Genre: Science / Technical
Publication date: TBD

 Research Articles and Book Chapters

  1. Majoros WH, Campbell MS, Holt C, DeNardo EK, Ware D, Allen AS, Yandell M, Reddy TE (2017) High-throughput interpretation of gene structure changes in human and nonhuman resequencing data, using ACE.  Bioinformatics 33:1437-1446
  2. Vockley CM, D'Ippolito AM, McDowell IC, Majoros WH, Safi AS, Song L, Crawford GE, Reddy TE (2016) Direct GR binding sites potentiate clusters of TF binding across the human genome.  Cell 166:1269-1281.
  3. Vockley CM, Guo C, Majoros WH (co-1st author), Nodzenski M, Scholtens DM, Hayes MG, Lowe WL, Reddy TE (2015) Massively parallel quantification of the regulatory effects of non-coding genetic variation in a human cohort.  Genome Research (Accepted)
  4. Ousterout DG, Kabadi AM, Thakore PI, Majoros WH, Reddy TE, Gersbach CA (2015) Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy. Nature Comm 6:6244.
  5. Ousterout DG, Kabadi AM, Thakore PI, Perez-Pinera P, Brown MT, Majoros WH, Reddy TE, Gersbach CA (2015) Correction of dystrophin expression in cells from duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases. Molecular Therapy 23:523-32.
  6. Majoros WH, Lebeck N, Ohler U, Li S (2014) Improved transcript isoform discovery using ORF graphs. Bioinformatics 30:1958-64.
  7. Majoros WH, Lekprasert P, Mukherjee N, Skalsky RL, Corcoran DL, Cullen BR, Ohler U (2013) MicroRNA target site identification by integrating sequence and binding information. Nature Methods 10:630-3.
  8. Pruteanu-Malinici I, Majoros WH, Ohler U (2013) Automated annotation of gene expression image sequences via non-parametric factor analysis and conditional random fields. Bioinformatics 29:i27-35.
  9. LaMonte G, Philip N, Reardon J, Lacsina JR, Majoros W, Chapman L, Thornburg CD, Telen MJ, Ohler U, Nicchitta CV, Haystead T, Chi JT (2012) Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. Cell Host and Microbe 12:187-99.
  10. Majoros WH, Ohler U (2010) Modeling the Evolution of Regulatory Elements by Simultaneous Detection and Alignment with Phylogenetic Pair HMMs. PLoS Computational Biology 6(12): e1001037
  11. Rach EA, Yuan HY, Majoros WH, Tomancak P, Ohler U (2009) Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome. Genome Biology 10:R73.
  12. Gene Prediction Methods (2009) Majoros WH, Ohler U.  In: Bioinformatics, Tools and Applications. Springer.  pp99-120.
  13. Majoros WH, Ohler U (2008) Complexity Reduction in Context-dependent DNA Substitution Models. Bioinformatics 25:185-82.
  14. Gottwein E, Mukherjee N, Sachse C, Frenzel C, Majoros WH, Chi J-T, Braich R, Manoharan M, Soutschek J, Ohler U, Cullen BR (2007) A viral microRNA functions as an ortholog of cellular miR-155. Nature 450:1096-1099.
  15. Majoros W, Ohler U (2007) Spatial preferences of microRNA targets in 3’ untranslated regions. BMC Genomics 8:152.
  16. Majoros W, Ohler U (2007) Advancing the State of the Art in Computational Gene Prediction. Proceedings of KDECB / Benelearn 06, Springer-Verlag.
  17. Allen J, Majoros W, Pertea M, Salzberg SL (2006) JIGSAW, GeneZilla, and GlimmerHMM: puzzling out the features of human genes in the ENCODE regions (2006)  Genome Biology 7(Suppl 1):S9.
  18. Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, and 37 others (2006) Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biology. 4(9).
  19. Nierman W, ... , Majoros WH (author 51 of 97), et al. (2005) Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438:1151-1156.
  20. Majoros WH, Pertea M, Salzberg SL (2005) Efficient implementation of a generalized pair hidden Markov model for comparative gene finding. Bioinformatics 21:1782-1788.
  21. Majoros W, Pertea M, Delcher A, Salzberg SL (2005) Efficient decoding algorithms for generalized hidden Markov model gene finders. BMC Bioinformatics 6:16.
  22. Anderson IJ, Watkins RF, Samuelson J, Spencer DF, Majoros WH, Gray MW, Loftus BJ (2005). Gene discovery in the Acanthamoeba castellanii genome. (2005). Protist 156:203-14.
  23. Dynamic programming for gene finders. (2005). Majoros WH.  In: Encyclopedia of Genetics, Genomics, Proteomics, and Bioinformatics.  Wiley. 
  24. Automatic concept identification in biomedical literature. (2005). Majoros WH.  In: Encyclopedia of Genetics, Genomics, Proteomics, and Bioinformatics.  Wiley.
  25. Majoros WH, Salzberg SL (2004) An empirical analysis of training protocols for probabilistic gene finders. BMC Bioinformatics 5:206.
  26. Majoros WH, Pertea M, Salzberg SL (2004) TIGRscan and GlimmerHMM : two open source ab initio eukaryotic gene finders. Bioinformatics 20:2878-2879. 
  27. The ENCODE Project Consortium (2004) The ENCODE (ENCyclopedia Of DNA Elements) Project. Science 306:636-640.
  28. Majoros WH, Pertea M, Antonescu C, Salzberg SL (2003) GlimmerM, Exonomy, and Unveil: Three ab initio Eukaryotic Genefinders. Nucleic Acids Research 31:3601-3604.
  29. Mi H, Vandergriff J, Campbell M, Marechania A, Majoros WH, Lewis S, Thomas PD, Ashburner M (2003) Assessment of genome-wide protein function classification for Drosophila melanogaster. Genome Research 13:2118-2128.
  30. Majoros WH, Subramanian GM, Yandell MD (2002) Identification of Key Concepts in Biomedical Literature using a Modified Markov Heuristic. Bioinformatics 19:402-407.
  31. Yandell MD, Majoros WH (2002) Genomics and Natural Language Processing. Nature Reviews Genetics 3:601.
  32. Holt RA, ... , Majoros WH (author 14 of 123), et al. (2002) The Genome Sequence of the Malaria Mosquito Anopheles gambiaeScience 298:129-149.
  33. Mural RJ, ... , Majoros WH (author 87 of 180), et al. (2002) A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome. Science 296:1661-1671.
  34. Majoros WH (2002) Syntactic Structure in Birdsong: Memetic Evolution of Songs or Grammars? Journal of Memetics, vol 6. (html)
  35. Venter JC, ..., Majoros WH (author 249 of 273), et al. (2001) The sequence of the human genome. Science 291:1304-1351.